Tom Davies returns from a one-match ban but Oumar Niasse has to sit out until the weekend through suspension.
Leighton Baines and Michael Keane both came off injured in the 4-1 defeat to Southampton on Sunday and will miss out here, leaving David Unsworth short of options at the back.
Wayne Rooney was an unused substitute at the weekend and will surely start here, while Morgan Schneiderlin faces the axe after another poor showing.
Andre Ayew was fit enough to come off the bench on Friday and may replace Marko Arnautovic in the starting XI after the latter was forced off against Leicester with a calf problem.
James Collins and Michail Antonio failed to overcome their respective injuries to feature against Leicester and they both remain doubts for the trip to Goodison Park.
Given West Ham played on Friday night, fatigue should not be too much of a problem and David Moyes may opt against several changes, although captain Mark Noble will push for a recall.
Pablo Zabaleta could be rested with an eye on a reunion with Manchester City just four days later, but with Sam Byram still sidelined, the 32-year-old may have to play here.
Leicester could name the same XI that drew 1-1 with West Ham on Friday night.
Claude Puel is again without Matty James, Robert Huth and Adrien Silva.
Erik Lamela missed the 1-1 draw with West Brom due to the birth of his child, but is an option for Mauricio Pochettino here and could make the bench.
Victor Wanyama and Toby Alderweireld are both ruled out for Tottenham, while Harry Winks is a doubt due to illness.
Pochettino could make a handful of changes, with Serge Aurier, Mousa Dembele, Moussa Sissoko and Danny Rose all in line to start.
There have been under 2.5 goals scored in Tottenham’s last 4 games (Premier League). Under 2.5 goals 2.09
There have been under 2.5 goals scored in Leicester’s last 3 home games (Premier League). Under 2.5 goals 2.09
Tottenham have scored at least 2 goals in 5 of their last 6 away matches against Leicester in all competitions. Over 1.5 goals 1.22
Pau Lopez is fit to start in goal for the home side after recovering from a muscle injury.
Mario Hermoso returns from suspension and should come straight back into the heart of the back four at the expense of Naldo.
Jose Manuel Jurado is expected to feature on the right-hand side of midfield, with Sergio Garcia taking the injured Leo Baptistao’s place up front.
No changes are expected for the visitors, who have been performing to very high standards of late in La Liga.
Franciso Portillo will retain his place on the right-hand side, with Angel leading the line with Jorge Molina.
Three of Getafe’s first-team regulars – Antunes, Mauro Arambarri and Juan Cala – are one booking from a suspension.
There have been under 2.5 goals scored in Espanyol’s last 6 games (La Liga). Under 2.5 goals 1.64
Espanyol have seen under 2.5 goals in 9 of their last 10 home matches against Getafe in all competitions. Under 2.5 goals 1.64
There have been over 2.5 goals scored in 6 of Getafe’s last 7 games (La Liga). Over 2.5 goals 2.20
Getafe have scored at least 2 goals in their last 3 matches (La Liga). Over 1.5 goals 1.39
Alvaro Gonzalez should return at centre-back for league action, with Daniele Bonera dropping to the bench.
Roberto Soriano will continue in midfield owing to the injury absence of Samu Castillejo.
No further changes should be made, with Javi Calleja’s side doing very well of late in La Liga.
Simon Kjaer misses out due to injury for the visitors, with Johannes Geis forced to play as a make-shift centre-back once again.
Nolito should be preferred to Joaquin Correa on the left, with Jesus Navas battling with Pablo Sarabia on the opposite flank.
Guido Pizarro and Steven N’Zonzi should start at the base of midfield, but Franco Vazquez did do well off the bench against Liverpool midweek.
Villarreal have kept a clean sheet in their last 4 home matches (La Liga). Villarreal win or draw 1.37
Villarreal have scored at least 2 goals in 10 of their last 12 home matches (La Liga). Over 1.5 goals 1.25
Sevilla have lost their last 4 away matches (La Liga). Sevilla lose 2.29
Sevilla have been losing at both half time and full time in their last 3 away matches (La Liga). Sevilla lose/lose 3.75
There have been over 2.5 goals scored in Sevilla’s last 4 games (La Liga). Over 2.5 goals 1.85
Villarreal have won their last 3 home matches (La Liga). Villarreal win 2.29
There have been under 2.5 goals scored in Villarreal’s last 3 games (La Liga). Under 2.5 goals 2.05
Sevilla are undefeated in 9 of their last 10 matches against Villarreal in all competitions. Sevilla win or draw 1.61
Liverpool are sweating on the fitness of Joel Matip, who has missed their last two matches with a thigh injury.
Trent Alexander-Arnold and Joe Gomez should continue to rotate at right-back, with the former getting the nod here.
Jordan Henderson had a terrible performance against Sevilla in midweek and Jurgen Klopp may contemplate dropping him against Chelsea.
Emre Can looks set to miss out as he is struggling with injury, while Alberto Moreno faces the chop after his horror performance in midweek.
Alvaro Morata, Tiemoue Bakayoko, Andreas Christensen and Gary Cahill will return to the starting XI on Saturday after being rested in midweek.
Eden Hazard may play up top with Morata, allowing Antonio Conte to pick three central midfielders. This decision would come at a cost to Willian and Pedro in the starting XI.
Victor Moses will make the bench for the away side, but lacks match fitness having not played in nearly six weeks.
Chelsea fact_7_name their last 3 away matches against Liverpool in all competitions. Chelsea win/draw 15.00
Liverpool have kept a clean sheet in 7 of their last 8 home matches (Premier League). Liverpool win or draw 1.33
Liverpool have drawn their last 3 home matches against Chelsea in all competitions. Liverpool draw 3.60
Chelsea have won 7 of their last 8 away matches (Premier League). Chelsea win 3.39
Liverpool have scored at least 3 goals in their last 3 matches (Premier League). Over 2.5 goals 1.64
Chelsea have kept a clean sheet in their last 3 matches (Premier League). Chelsea win or draw 1.70
There have been over 2.5 goals scored in Liverpool’s last 4 games (Premier League). Over 2.5 goals 1.64
Liverpool have won their last 3 matches (Premier League). Liverpool win 2.20
There have been over 2.5 goals scored in 5 of Chelsea’s last 6 away games (Premier League). Over 2.5 goals 1.64
Liverpool have seen under 2.5 goals in their last 3 home matches against Chelsea in all competitions. Under 2.5 goals 2.20
Chelsea are undefeated in their last 6 away matches against Liverpool in all competitions. Chelsea win or draw 1.70
Marko Arnautovic is a doubt having been forced off in the 2-0 loss to Watford last time out, which could pave the way for Andre Ayew to start on the right, though he is struggling through illness.
David Moyes is without Sam Byram, Jose Fonte and Chicharito for Friday’s welcome of Leicester.
Moyes is also sweating on the fitness of Michail Antonio and James Collins here.
Matty James and Robert Huth are again ruled out through injury, while Adrien Silva is unable to feature until January.
Claude Puel could name the same XI that started the 2-0 loss to Manchester City.
West Ham have conceded at least 2 goals in their last 4 matches (Premier League). Over 1.5 goals 1.28
Leicester are undefeated in their last 6 matches against West Ham in all competitions. Leicester win or draw 1.44
West Ham have failed to win their last 5 matches (Premier League). West Ham lose or draw 1.44
~ David Moyes’ West Ham managerial career got off to the worst possible start with a 2-0 loss to Watford. The Hammers have now failed to win their last five, losing three, which sees them occupy a relegation spot.
~ Leicester fell to a first defeat in six at the hands of Manchester City last weekend, but are unbeaten in their last four away from home, drawing three. The Foxes are unbeaten in their last six competitive meetings with West Ham and have won their last two visits to east London.
~ They could extend that run to three wins in the capital on Friday night.
Previous Meetings (Last 6 matches)
EPL 18-03-2017 FT West Ham 2 : 3 Leicester
EPL 31-12-2016 FT Leicester 1 : 0 West Ham
EPL 17-04-2016 FT 1Leicester 2 : 2 West Ham
EFLC 22-09-2015 AET Leicester 2 : 1 West Ham
EPL 15-08-2015 FT 1West Ham 1 : 2 Leicester
EPL 04-04-2015 FT Leicester 2 : 1 West Ham
TV / Live Streaming
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FC Koln are without first team regulars Jonas Hector, Marcel Risse and Domenique Heintz for the visit of Arsenal.
Elsewhere Marco Hoger is also out, while Christian Clemens is nearing a return.
Leonardo Bittencourt did make a timely return from injury at the weekend and could start on the left in place of Simon Zoller, who was forced off early on against Mainz and will be out until the New Year.
Santi Cazorla is the only certain absentee for Arsenal, who will hope to have Olivier Giroud and Theo Walcott back in contention from a thigh problem and illness respectively.
David Ospina and Matt Macey are vying for a spot between the posts, while Per Mertesacker may start at the heart of the defence having missed out at the weekend.
Eddie Nketiah will be hoping to make his first start for the senior side if Giroud nor Welbeck can recover in time, alongside fellow academy graduates Reiss Nelson and Joe Willock.
Arsenal have won their last 3 matches against FC Cologne in all competitions. Arsenal win 2.39
FC Koln have seen over 2.5 goals in their last 3 matches against Arsenal in all competitions. Over 2.5 goals 1.85
Arsenal have scored at least 2 goals in their last 3 matches against FC Cologne in all competitions. Over 1.5 goals 1.25
Paulo Dybala, Gianluigi Buffon, Blaise Matuidi, Mattia De Sciglio and Alex Sandro were all rested at the weekend and will come back into the starting XI on Wednesday.
Douglas Costa and Mario Mandzukic are in competition to start on the left flank against Barcelona.
Gerard Pique is available again after serving a one-match ban last time out in the competition.
Nelson Semedo and Andrés Iniesta were brought off just before the hour mark at the weekend to ensure they are fresh for Wednesday.
Semedo will incur a one-match ban with his next booking.
Paulinho will be pushing for a start and could replace Ivan Rakitic in central midfield in Turin.
Juventus are undefeated in 17 of their last 19 matches (UEFA Champions League). Juventus win or draw 1.55
Juventus have seen over 2.5 goals in their last 3 home matches against Barcelona in all competitions.
Barcelona are undefeated in their last 5 matches (UEFA Champions League). Barcelona win or draw 1.37
Daniel Carriço and Nico Pareja are sidelined, while Sergio Escudero is one booking away from suspension.
Michael Krohn-Dehli and Guido Pizarro are vying for a starting role in central midfield against Liverpool.
Simon Kjaer came off the bench at the weekend, which should see him return at centre-back against Liverpool at the expense of Johannes Geis.
A thigh problem kept Joel Matip out of Liverpool’s 3-0 win over Southampton at the weekend and he will miss out here as well.
Adam Lallana is nearing a return to first-team football but hasn’t featured at all this season and will be managed carefully.
Sadio Mane has been dealing with a hamstring injury and may not be risked after starting against Southampton, which could benefit Alex Oxlade-Chamberlain, Dominic Solanke or Daniel Sturridge here.
Joseph Gomez is expected to start at right-back after Trent Alexander-Arnold got the nod on Saturday, while Loris Karius will continue in goal.
Emre Can and James Milner are also pushing for starts here.
There have been over 2.5 goals scored in Sevilla’s last 6 games (UEFA Champions League). Over 2.5 goals 1.57
There have been over 2.5 goals scored in 5 of Liverpool’s last 6 games (UEFA Champions League). Over 2.5 goals 1.57
Liverpool are undefeated in their last 8 matches (UEFA Champions League). Liverpool win or draw 1.41
Sevilla have scored at least 2 goals in 5 of their last 6 matches (UEFA Champions League). Over 1.5 goals 1.16
Liverpool have scored at least 2 goals in 5 of their last 6 matches (UEFA Champions League). Over 1.5 goals 1.16
Davy Pröpper was fit enough to start for Holland against Romania during the week after struggling with an ankle injury earlier this month. He should be fine to start against Stoke on Monday.
Chris Hughton has a relatively settled starting XI and no changes are expected from the Brighton manager here.
Brighton will have to check on Mat Ryan following his late return from international duty with Australia, but he should be okay to start on Monday.
Jack Butland may not feature again before Christmas after breaking a finger during the international break, with Lee Grant set to deputise between the sticks.
Geoff Cameron still hasn’t managed to train properly due to a few problems and is a major doubt for Monday’s trip to Brighton, but the international break should have given Glen Johnson the chance to overcome illness.
Peter Crouch came off the bench to score the equaliser against Leicester before the international break and he will be pushing for a first league start this season.
Jesé has been out of action for a while but Mark Hughes will hope he can start for the Potters on Monday.