Ronald Koeman is expected to make some changes to the side that drew 1-1 with Brighton at the weekend.
Oumar Niasse is ineligible for the home side, while the Everton manager will be without at least five players because of injury.
Ashley Williams and Phil Jagielka may rotate in the starting XI here, with the former coming into the team against Lyon.
Memphis Depay has dropped down the pecking order in recent weeks but should be given a chance to impress from the start against Everton on Thursday.
Marcelo missed Friday’s win over Monaco through suspension and will be fresh to return to the team at Goodison Park. Rafael and Kenny Tete may also continue to rotate at right-back.
Clement Grenier and Pape Cheikh are both expected to miss out for the away side.
Group E is completely open at this stage after just one win between all four teams. Lyon have drawn both of their matches, while Everton are bottom of the group on one point.
Everton have only won two of their last 11 matches in all competitions and are really struggling to get out of their current funk.
Lyon will be high on confidence after beating Monaco 3-2 on Friday, but that was only their second win in nine competitive matches.
Not only that, Lyon are winless in four away matches in Europe and have lost five of their previous eight matches away to English sides.
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