Paulo Dybala, Gianluigi Buffon, Blaise Matuidi, Mattia De Sciglio and Alex Sandro were all rested at the weekend and will come back into the starting XI on Wednesday.
Douglas Costa and Mario Mandzukic are in competition to start on the left flank against Barcelona.
Gerard Pique is available again after serving a one-match ban last time out in the competition.
Nelson Semedo and Andrés Iniesta were brought off just before the hour mark at the weekend to ensure they are fresh for Wednesday.
Semedo will incur a one-match ban with his next booking.
Paulinho will be pushing for a start and could replace Ivan Rakitic in central midfield in Turin.
Juventus are undefeated in 17 of their last 19 matches (UEFA Champions League). Juventus win or draw 1.55
Juventus have seen over 2.5 goals in their last 3 home matches against Barcelona in all competitions.
Barcelona are undefeated in their last 5 matches (UEFA Champions League). Barcelona win or draw 1.37
~ Juventus have to beat Barcelona to have any chance of catching the Spanish giants at the top of Group D but have not prepared in the ideal fashion after losing 3-2 to Sampdoria at the weekend.
~ Barcelona are unbeaten in all competitions this season and have only failed to win on two occasions. Luis Suarez also ended his poor spell in front of goal with a brace at the weekend, which makes things more challenging for Juventus.
~ Juventus have only won two of their last five in the Champions League and face the prospect of losing at home in the competition for the first time since April 2013.
Previous Meetings (Last 6 matches)
UCL 12-09-2017 FT Barcelona 3 : 0 Juventus
ICC 22-07-2017 FT Juventus 1 : 2 Barcelona
UCL 19-04-2017 FT Barcelona 0 : 0 Juventus
UCL 11-04-2017 FT Juventus 3 : 0 Barcelona
UCL 06-06-2015 FT Juventus 1 : 3 Barcelona
UCL 22-04-2003 AET Barcelona 1 : 2 Juventus
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